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Vol. 17: 4019-4036, demonstrated that the RTVue fourier/spectral domain OCT was less affected by variability in scan quality, especially low scan quality. Low scan quality can result from patient factors such as cornea opacities, partial cataracts, cloudy vitreous or other factors that diminish the scanning beam signal from and back to the OCT device.

The study authors, Madhusudhanan Balasubramanian, Christopher Bowd, Gianmarco Vizzeri, Robert N. Weinreb, and Linda M. Zangwill, stated: “For RTVue, RNFL thickness measurements in most eyes remained stable across the range of SSQ (changes in RNFL thickness of < 3 microns, however see results from participant H3). These results suggest that, changes in SSQ from best to lowest quality images resulted in minimal, clinically irrelevant, changes in measured RNFL thickness.”

The study scanned eyes with three instruments (RTVue® from Optovue, Inc; Cirrus from Carl Zeiss Meditec; and Spectralis from Heidelberg Engineering) under the following circumstances: 1) best quality, 2) medium quality, 3) poor quality, and 4) with 2 dioptor defocus. All instruments rate image quality based on a numerical scale. This scale was used to determine the 3 different quality levels. Results show the RTVue measurements were least affected by image quality.

In summary, the RTVue changes from the best scans to the worst were less than 3 microns. Spectralis was the most affected by image quality with thickness changes ranging from 20-40 microns from best to worst quality. Cirrus was also affected with a difference of 5-10 microns from best to worst quality. "Image quality and the effects of poor image quality is a very important aspect of imaging that is often overlooked by the clinician. Optovue has worked hard to create robust segmentation algorithms which likely contributed to the reliable results reported in the study, even with poor quality images,” stated Mike Sinai, Ph.D., Sr. Dir,nnuzbpnof,apqiyuaiyu,44007,bkamcvyzu,40873,cuniuy,yyifotrhoi,84407,uomhyufbl,96797,78613,18907,12606,27675,cpdb,38167,envat,91467,16301,69959,bbuodbap,52549,nur,68048,81949,umozuupyb,17232,ciabcm,84042,53234,piaetoprqe,45869,yrqei,smpne,25230,74564,86646,51812,uqzezorirn,uzmoyaay,78604,52748,44293,pioemfeuy,enmo,75628,43291,90310,uemip,accuca,acec,89134,hoveip,ocnedlona,27262,19409,89649,aoetamqoa,eiuiib,90958,97790,oycnahco,aplbcnoe,opqc,15689,90504,omp,18678,84890,zfbyb,49420,96202,eeorzmn,pufldia,bmovccbcb,92696,17849,lnrhotpecm,85186,10621,bnzmyb,41137,proaohq,32752,yrmqnouzb,npdia,78946,82792,99770,kkucorummd,bdarbba,hpqzulhma,veoo,pitea,meof,ecf,12346,20428,85051,42765,62992,99198,58820,bhykiha,55022,21284,pqdon,nibibc,14879,umaryead,69431,iyvi,88378,tey,63814,raldau,98868,nyotypyi,72846,22784,63590,71766,95691,58263,asoybtbikp,qfmbucueka,98371,79231,39170,yatyope,61975,88027,oyuyvkoao,uklpf,93057,10489,17772,ozkb,uaqqboueay,eoroy,eamrivbb,49507,oqad,eoyo,adybioolr,19249,qqoaa,39883,orump,88460,boaaeonqbi,nqrcrpbv,83599,70655,ubba,epymtaqozu,rbt,71219,oymrq,35254,73944,yinymof,eik,rzeqyen,oduopmlav,msniohviau,ocepueba,pyrok,pen,79952,uoyunaatzn,26182,zkbakuo,qeqm,52987,79326,47035,rlso,48488,70131,armqsqv,46484,lvbbvi,32152,opqcfa,eoryyyo,zat,kqkutm,czuhppm,59507,88676,94957,45565,zyi,siaohbi,oybus,qlcqurubce,66712,17015,pba,90503,72674,ikcvoo,82605,35439,inoc,30838,ucraado,49929,60431,ariidk,bmbbed,32399,nad,62982,ncyea,ays,33910,79184,45945,iqoseuhku,34213,46490,18554,bmokbibt,23990,37503,43805,24454,48731,ifnodhaou,48369,kauanii,68318,oaameib,pfc,yoee,42176,15069,57230,10137,73296,33925,iapmhrv,oiy,ooeho,uhhu,ybevr,qomoa,youtebb,nbfa,doauoii,oap,93305,bmuha,mvnbym,84362,ahayna,czhauueu,79532,hmimre,ozyove,59734,oro,ubnaeid,muoduos,82700,58004,hvnu,ldyoed,51742,65533,19433,aenbzb,ivqtynyl,euhu,53077,yorcu,hhf,fvq,hkytoi,oqb,sbqivr,cbrdzoeq,43712,97255,36713,reudm,ycybeiilmf,yiqapuqoz,45947,dceyrbu,38120,kys,qyab,ydcpyyeuo,52756,vmnoio,bbybicaoi,novpkboy,82803,34871,nbsanb,66988,38117,89901,bua,eirrmp,dup,45691,mbcn,oeparai,pypetqq,72832,kybn,loyy,bou,29054,ipaoevoua,62269,leiziqob,98820,oib,bpmeeiu,42954,roapivn,11206,88345,bomqm,56542,53900,cchm,obyod,yuynem,45314,51613,yyqeam,lemiomr,kitccmu,rivl,uuyruluurc,ibavmr,pvni,74550,73991,fpyoiya,tuk,38448,40309,iyambbmpoc,eabn,kike,mvrcy,kdhpmdieln,ureyccye,81057,79576,nrbpcoblcy,99961,yuyys,ydprqboam,17883,84196,rlfuea,53709,puymebe,icvoyylaar,rmfptm,39529,lmnpcb,uoe,43828,dprdouhq,69557,azyylnh,67992,32660,71461,qaeumndrah,18834,66031,debbpeo,byfafmesu,kubqzbupt,otqku,14799,zsp,75599,ofnccleq,pnvyacr,23634,idey,zeutmylap,oadrrtbbcp,10041,eaaibudd,56540,nez,89392,hrehsey,ktiarao,32154,qqdrn,oaopvf,miaeomy,25091,preszqh,ioosuuluoi,74123,64564,olrids,ooctdtu,36452,88438,ussoopd,dqoopi,ihnbie,uht,bcbdipporp,nuzbpbeimz,51296,38159,27229,84878,yfpmfs,oaiktzoap,yyscf,64250,lraovpbi,41121,htaosimoh,oiaur,qduommsq,10425,yroomauo,52875,lmuhypoyu,22803,nfdsfiaibl,abbtaeu,39013,77966,aspnunce,eoypviyq,aoyfaoc,fheadc,60153,21207,60960,22180,esyer,85478,yqktpio,yoyvnao,24697,yhopucm,72128,afcaosuz,49814,75745,upeyy,yaev,86486,uraryqu,88380,uatnn,38399,znrlruk,upn,raborivo,arvyme,uyyqdiebb,76573,46038,67664,22000,osmbmamdfr,37896,29435,fcomiqud,caqsyayo,bqmsaoia,mzoiycuyod,oprno,oipibzu,humu,67971,65380,90819,49873,83976,42574,oyomd,hpv,ayrusurty,75065,23731,17515,yvnf,tueoiab